• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    respiratory drug delivery device and compliance and feedback device for use with a medicine storage and delivery device a respiratory drug delivery device includes a medicine storage and delivery device having an outlet and a coupled feedback and compliance device the same. the feedback and compliance device has an opening, and the output from the medication storage and delivery device is received through the opening. the feedback and compliance device includes: (i) one or more sensors, each of the one or more sensors being structured to detect a parameter related to the use of the respiratory medication administration device without modifying or interfering with the medication flow introduced by the action the drug storage and delivery device, feedback devices, and (iii) one (ii) one or more processing units programmed to cause the one or more feedback devices to provide feedback information to a patient related to the use of the respiratory drug delivery apparatus, based on an output from at least one of the one or more sensors.
    公开号:BR112012016540B1
    申请号:R112012016540-2
    申请日:2010-12-07
    公开日:2020-03-24
    发明作者:Dirk Ernest Von Hollen；Jonathan Stanley Harold Denyer
    申请人:Koninklijke Philips N.V.；
    IPC主号:
    专利说明:

    RESPIRATORY MEDICINE ADMINISTRATION AND FEEDBACK DEVICE AND COMPLIANCE FOR USE WITH A MEDICINE STORAGE AND ADMINISTRATION DEVICE
    The present invention relates to an apparatus for administering a respiratory medication to a patient, and in particular to a respiratory medication administration apparatus which includes a feedback and compliance device which provides feedback to a patient regarding the use of the apparatus. respiratory medication administration, particularly in situations where the patient is required to self-medicate regularly using the respiratory medication administration apparatus.
    It is known to administer a medication to a patient's respiratory system to treat a medical condition using a respiratory medication delivery apparatus. For example, a patient suffering from an acute asthma attack can use a respiratory medication delivery device to administer a bronchodilator, such as albuterol (salbutamol), in the form of a fine mist, to the patient's respiratory system.
    A known respiratory drug delivery device consists of a metered dose inhaler (MDI) and a spacer or valve support chamber. MDI, also known as simply an inhaler, includes a container or nebulizer that contains the medicine under pressure, and a container holder, usually called a boot, which is typically L-shaped. Although it is common for a patient to use the boot as a mouthpiece to receive the aerosolized medicine into his airway directly from the aerosol dispensing leg of the boot, this configuration may not optimize the mixture of the medicine with the air, because the
    2/23 aerosolized medication is injected directly into the airway. Without the proper mixing of the medicine with the air, the medicine may not be inhaled into the patient's lungs where it is effective, but may be formed by droplets that are deposited in the patient's mouth and swallowed without the desired medicinal effect.
    To improve the mixing of the medicine with the air, it is known to provide a spacer, also generally called a valve support chamber, which attaches to the aerosol dispensing end of the boot. The spacer, which is typically a small hollow cylinder with a unidirectional valve at the downstream end, receives the aerosol from the container and allows it to be formed in a fine mist for inhalation through the patient's airway. Optionally, a mask can be provided at the end of the spacer opposite the MDI, so that the patient can breathe through his mouth to receive the medication. Examples of conventional spacers and associated components are shown in US patents 4,470,412; 4,809,692; and 4,832,015, 20 all by Nowacki et al .; in US patent 5,012,803, by Foley et al. ; US patent 5,042,467 to Foley; in US patent 5,385,140, to Smith, US patent 5,848,599, to Foley et al .; and in US patent 6,557,549, by Schmidt et al. Other known respiratory drug delivery devices include dry powder inhalers (DPIs) and nebulizers.
    Proper use of a medical device as a respiratory drug delivery device is essential, particularly in situations where a patient is required to self-medicate regularly to manage his disease condition. This is often the case in situations of respiratory disease in which the patient is
    3/23 typically provided with a respiratory drug delivery device and whether it is expected to self-manage your respiratory disease condition using the respiratory drug delivery device.
    • 5 Usually, a medical professional will provide the patient with initial education on how to use the respiratory medication delivery device to properly self-administer the respiratory medication. As will be appreciated, the effectiveness of this training method is largely based on the knowledge and technical level of the medical professional, as well as the amount of time this professional can spend with the patient, which is often limited.
    In the area of administration of respiratory drugs, several assessments were conducted to quantify the level of knowledge of medical professionals on the proper administration of drugs using a device for administering respiratory drugs such as an MDI or an MDI with a valve support chamber.
    Unfortunately, such assessments were not encouraging. One study in particular, involving medical professionals, indicated that the percentage of participants who correctly completed the appropriate steps for using a separate MDI was 67.6%, the percentage of participants who correctly completed the 25 appropriate steps for using an MDI with a spacer was
    49.9%, and the percentage of participants who correctly completed the appropriate steps for using a nebulizer was 38%. This study was reported in Laura T. Scarpaci, Pharm.D., Assessment of Hospice Nurses' Technique in the Use of Inhalers and Nebulizers, Palliative Medicine Vol. 10. No. 2, 2007. Another study aimed at medical professionals in an environment hospital related to the use of MDI and spacer showed that only 5% used an MDI perfectly. This
    4/23 improved to 13% after a class and demonstration, and 73% after intensive individual sessions. This study was reported in M. Lee-Wong, Results of a Programe to Improve House Staff Use of Metered Dose Inhalers and Spacers, Post Graduate Medical Journal, Vol. 79, pages 221 to 225, 2003.
    Another study was conducted to quantify the level of knowledge of patients about the administration of the drug using a separate MDI. The results indicated that 28% to 68% of patients did not use their MDI effectively. In addition, a patient's reading level was correlated with inadequate techniques of using an MDI. Specifically, a poor technique, identified as three or fewer steps being performed, was found in 89% of patients who read at the third grade level and in 48% of patients who read in high school. This study was reported in James B. Fink, Problem with Inhaler Use: Ά Call for Improved Clinician and Patient Education, Respiratory Care, Vol. 50, No. 10, September 2005.
    In addition, medical devices such as respiratory drug delivery devices are typically provided with a set of written instructions. However, such instructions, in many cases, are not read by the patient and / or are not consulted and / or used while using the device (patients can discard the instructions or store the instructions separately from the device itself).
    Thus, it is evident that there is a long-standing but unresolved need for a respiratory drug delivery device, which improves treatment by encouraging the appropriate use of the device by the patient. This is particularly true in situations that require patients to self-medicate, separated from the supervision of a medical professional, as is often the case with management.
    5/23 of respiratory diseases.
    In one embodiment, a respiratory drug delivery device is provided, which includes a drug storage and delivery device, such as a metered-dose inhaler, a dry powder inhaler or an aqueous liquid dispensing system, having an outlet and a feedback and compliance device coupled to the medication storage and delivery device. The feedback and compliance device has an opening, and the output from the medication storage and delivery device is received through the opening. The feedback and compliance device includes: (i) one or more sensors, each of the one or more sensors being structured to detect a parameter related to the use of the respiratory medication delivery device without modifying or interfering with the flow of medication introduced by the action the medication storage and delivery device, (ii) one or more feedback devices, and (iii) a processing unit programmed to cause the one or more feedback devices to provide feedback information to a patient related to the use of the respiratory drug delivery apparatus, based on an output from at least one of the one or more sensors. Feedback information can be audible, visual, or tactile, or any combination of them.
    In another embodiment, a method of encouraging the proper use of a respiratory drug delivery device including a drug storage and delivery device is provided. The method includes the provision of a feedback and compliance device, in which the feedback and compliance device includes one or more sensors, each of the one or more sensors being structured to detect a parameter related to a
    6/23 respiratory medication delivery device, without modifying or interfering with the flow of medication introduced by the action of the storage and medication delivery device, coupling the storage and medication delivery device to the feedback and compliance device by inserting an output from the medication storage and delivery device through an opening provided in the feedback and compliance device, and provide feedback information to a patient related to the use of the respiratory medication delivery device, based on an output of at least one of the one or more sensors.
    These and other objects, elements and features of the present invention, as well as the methods of operation and functions of the related elements of the structure and the combination of parts and manufacturing economies, will become more apparent after considering the following description and appended claims, with reference to the accompanying drawings, all of which form a part of this document, in which 20 similar reference numerals designate corresponding parts in the various Figures. It should be expressly understood, however, that the drawings are for the purpose of illustration and description only, and are not intended to be a definition of the limits of the invention. As used in the specification and the claims, the singular form of one, one, and (a) include plural references, unless the context clearly indicates otherwise.
    Figures 1 and 2 are front and rear isometric views, respectively, of a respiratory drug delivery apparatus 30 according to a particular embodiment of the invention;
    Figure 3 is a side cross-sectional view of the respiratory medication delivery device of the
    7/23
    Figures 1 and 2 inserted into a patient's mouth;
    Figure 4 is a block diagram of the feedback and compliance device of the respiratory drug delivery apparatus of Figures 1 and 2, according to a particular embodiment;
    Figures 5 to 7 are side cross-sectional views of the respiratory drug delivery device of Figures 1 and 2 inserted into a patient's mouth, which illustrate various aspects of the operation of the respiratory drug delivery device.
    Figures 8A and 8B are a flow chart illustrating the operation of the respiratory drug delivery apparatus of Figures 1 to 7, in accordance with a particular non-limiting embodiment of the invention;
    Figure 9 is a front isometric view of a respiratory drug delivery device according to another particular embodiment of the invention;
    Figures 10 and 11 are isometric front and rear views, respectively, of a respiratory drug delivery apparatus according to an alternative exemplary embodiment of the invention;
    Figure 12 is a side cross-sectional view of the respiratory drug delivery apparatus of Figures 10 and 11.
    Orientation expressions used in this document, such as, for example, and without limitation, top, bottom, left, right, top, bottom, front, rear (a), and derived from them, are related to the orientation of the elements shown in the drawings and do not limit the claims, unless expressly stated in them.
    As used in this document, the statement that two or more parts or components are coupled must
    8/23 means that the parties are united or operate together, directly or through one or more intermediate parts or components.
    As used in this document, the statement that two or more parts or components engage with each other must mean that the parties exert a force against the other, directly or through one or more intermediate parts or components.
    As used in this document, the term number must mean one or an integer greater than one (that is, a plurality).
    Figures 1 and 2 are isometric front and rear views, respectively, of the respiratory drug delivery apparatus 2 according to a particular embodiment of the invention; Figure 3 is a side cross-sectional view of the respiratory medication delivery device 2 inserted into the patient's mouth 4. The respiratory medication delivery device 2 includes the valve support chamber 6 which is structured for use in connection with the metered-dose inhaler (MDI) 8 having the container 10 received inside the boot 12, as described elsewhere in this document. The valve support chamber 6 includes the generally cylindrical main chamber 14 having the unidirectional inhalation valve 16 (Figure 3), such as a duckbill valve, coupled to the front end thereof. In an exemplary embodiment, the main chamber 14 is made of a transparent and antistatic material. In addition, the mouthpiece assembly 18 is coupled to the front end of the main chamber 14 and includes the mouthpiece 20 structured to be received on the patient's lips 4 during the use of the respiratory medication delivery device 2 and the exhalation valve element 22 operatively coupled to it, the
    9/23 which, in the illustrated embodiment, is in the form of a flap exhalation valve.
    The respiratory drug delivery apparatus 2 additionally includes the two-part MDI adapter 24, which is structured to be removably attached to the end of the main chamber 14 which is opposite the mouthpiece assembly 18 (i.e., the rear end). The MDI adapter 24 is structured to receive and hold the MDI 8. The two-part MDI adapter 24 includes the rigid end cap 26 made of, for example, a hard plastic or other suitable rigid material that is structured to be selectively Attachable to the rear end of the main chamber 14. The two-part MDI adapter 24 additionally includes the flexible inner portion 28 made of a flexible material, such as, without limitation, silicone, rubber, TPE, or foam, among other suitable materials. The inner portion 28 is structured to be received and secured by the end cap 26 and can be made to be removable, so that it can be cleaned and / or replaced if damaged, or, alternatively, can be permanently attached to the cap. end 26, by a process such as an overmoulding process. The flexible inner portion 28 includes walls that define a structured opening to receive the boot 30 output from MDI 8. The flexible nature of the inner portion 28 allows it to hold MDIs of different shapes and sizes.
    As is known in the art, and as described in more detail in this document, in connection with a particular embodiment of the invention, when the valve support chamber 6 is used by patient 4, patient 4 shakes the MDI 8 and the support chamber valve 6, inserts the nozzle 20 into your mouth and exhales, to, at least partially, empty gas from your lungs. Exhaled gases
    10/23 are, through the operation of the exhalation valve element 22, allowed to flow within the nozzle assembly 18 into the ambient atmosphere, through one or more exhalation ports that are covered by the exhalation valve element 22.
    Such gases are not, as a result of the operation of the unidirectional inhalation valve 16 provided inside the main chamber 14, allowed to flow into the main chamber 14. After exhalation, patient 4 acts on MDI 8 to cause a dose of medication (in the form of an aerosol mist 10) is sprayed into the main chamber 14, and after that, begins to inhale. During inhalation, the unidirectional inhalation valve 16 allows fluid to flow from the main chamber 14 to the nozzle assembly 18, and out through the nozzle 20, so that medication 15 (mixed with air in the main chamber) 14) can be deposited within the lungs of the patient 4. This process can be repeated one or more times, depending on the needs of the particular patient.
    The respiratory drug delivery device 2 additionally includes the feedback and compliance device 32, which is removably attached to the rear end of the MDI adapter 24. The feedback and compliance device 32 can be attached to the rear end of the MDI adapter 24 by a mechanical connection mechanism or by an adhesive. For example, Figure 9 shows a particular embodiment, in which the feedback and compliance device 32 is capable of being selectively coupled to the rear end of the MDI adapter 24 using a mechanical connection mechanism that includes a connector 64 extending from of the feedback and compliance device 32, which is structured to be received and secured within the groove 66 provided in the MDI adapter 24. Alternatively, the feedback and compliance device 32 can be attached to the rear end of the MDI adapter 24 and secured in place as a result of output 30 of boot 12 being secured by the inner portion 28 of the MDI adapter 24, in this case, the feedback and compliance device 32 will be trapped and sandwiched between the MDI adapter 24 and the MDI 8. In a Alternatively, the feedback and compliance device 32 can be incorporated as part of the MDI adapter 24 in a one-piece assembly. This would allow the patient or caregiver to promptly exchange such a one-piece set for an existing camera adapter.
    The feedback and conformity device 32 includes external encapsulation 32, which, in the exemplary embodiment, is made of a rigid material, such as a hard plastic or some other suitable rigid material. External encapsulation 34 includes central recess 36, which is structured to receive the bottom of boot 12 of MDI 8, and includes an opening, so that the bottom of boot 12, and specifically, outlet 30 of boot 12 of MDI 8, can be inserted through the external encapsulation 34, and received and secured by the flexible inner portion 28 (Figure 3). As described in more detail in this document, the feedback and compliance device 32 is structured to automatically monitor patient use of the respiratory medication delivery device 2 and provide feedback in the form of instructions and compliance information related to proper use. from the respiratory medication delivery device 2 to patient 4, without interfering with the dispensing of medication from container 10 of MDI 8 (for example, the amount of the dose administered will not be affected). External encapsulation 34 includes channel 38, which is in fluid communication with channel 40, provided on end cap 26 of the MDI adapter 24, when the feedback and compliance device 32 is coupled to the end
    12/23 rear of the MDI adapter 24. The purpose of channels 38 and 40 is described elsewhere in this document.
    Figure 4 is a block diagram of a feedback and compliance device 32 showing the selected components thereof, according to a particular embodiment. The positioning of some of these components, so as not to interfere with the dispensing of medication from the MDI 8 container 10, in this particular embodiment, is shown in Figure 3. The feedback and compliance device 32 includes the processing unit 42, the which can include a microprocessor, or any other suitable processor, which is operatively coupled to a memory suitable for storing programs / routines to be executed by the processing unit 42. Specifically, the memory, which can be separated and / or internal to the microprocessor, microcontroller or other suitable processor, stores one or more routines to control the operation of the feedback and compliance device 32 described in greater detail elsewhere in this document. The feedback and compliance device 32 also includes battery 44, or a similar power supply, to supply power to the components of the feedback and compliance device 32.
    One or more IR sensors 46 are operatively coupled to the processing unit 42. In the exemplary embodiment, as seen in Figures 1 and 3, two IR sensors 46 are provided on an upper portion of the front end of the outer package 34. In reference to Figure 5, the first of the IR sensors 46 is structured to detect the distance between the front end of the outer package 34 and the patient's face 4, as indicated by the dotted line in Figure 5, to determine whether the delivery device respiratory medicine 2
    13/23 is held in place, in front of patient 4's face. As described in greater detail below, this information can be used in connection with fluid flow information to determine whether patient 4 is holding his breath as instructed. Also in reference to Figure 5, the second of the IR sensors 46 is structured to detect the operation of the exhalation valve element 22 and thus the exhalation by the patient 4, as indicated by the arrow in Figure 5, detecting the movement of the exhalation valve element 22, or the sound, or the temperature of the air moving through the exhalation valve element 22.
    In addition, one or more LEDs 48 and screen 50, such as an LCD screen, are operatively coupled to processing unit 42. In the exemplary embodiment, as seen in Figures 1 and 3, a first plurality of LEDs 48 is provided on the portion The upper end of the front end of external housing 34, and a second plurality of LEDs 48 and screen 50, in the form of an LCD screen, are provided on the side of external housing 34. LEDs 48 and screen 50 are structured to provide visual information, such as as patient feedback and instructions 4, as described in more detail in this document. Optionally, a tactile feedback device, such as a vibrator, can be coupled to the processing unit 42 to provide feedback and instructions to the patient 4, which are tactile in nature.
    The feedback and compliance device 32 also includes several additional sensors that are operatively coupled to the processing unit 42. In particular, an accelerometer 52, or other suitable motion detection device, is provided as part of the feedback and compliance device 32 for detect when the respiratory medication delivery device 2 is being
    14/23 agitated, or moved in another way by patient 4. In this exemplary embodiment shown in Figure 3, the accelerometer 52 is provided in channel 58, provided in the external encapsulation 34 above channel 38.
    In addition, flow sensor 54 is provided as part of the feedback and compliance device 32 for detecting fluid flow through channels 38 and 40 and main chamber 14, and thus inhalation of patient 4. In this exemplary embodiment shown in Figure 3, flow sensor 54 is provided adjacent to channel 38 in external housing 34. flow sensor 54 can be, without limitation, a MEMS type flow sensor. Referring to Figure 6, the fluid flow resulting from the actuation of MDI 8 is shown by arrow A, and the air flow through channels 38 and 40, due to inhalation, is shown by arrow B. Alternative methods and mechanisms for detecting inhalation by patient 4 can also be employed. For example, a pressure differential between outlet 30 and channel 40 can be monitored, which will change when patient 4 is inhaling. In addition, an acoustic microphone can be provided in encapsulation 34 to hear and detect sounds indicative of inhalation by the patient 4. As another alternative, a temperature sensor can be provided in encapsulation 34 to monitor the temperature inside the main encapsulation 14 and detect a temperature change resulting from the removal of the aerosol mist introduced by the actuation of the MDI 8 due to inhalation by the patient 4. As another alternative, an IR sensor, or acoustic movement sensor, can be provided in the encapsulation 43 to detect the movement of the valve of unidirectional inhalation 16 due to inhalation by the patient 4.
    Finally, the load cell or extensometer 56 is provided as part of the feedback and compliance device
    15/23 to detect generally downward forces applied to it by boot 12 of MDI 8. Such downward forces may result from the insertion of MDI 8 into the feedback and compliance device 32 and the actuation or firing of the MDI by the patient 4 (where the detection of associated forces can be used to detect such actions). In this exemplary embodiment shown in Figure 3, the load cell or extensometer 56 is provided adjacent to channel 58 in the external package 34. Referring to Figure 7, the displacement of the boot 12 due to the force that is applied to the container 10 to act or fire MDI 8 is shown by the arrows located adjacent to boot 12 (boot 12 is capable of rotating in relation to the external encapsulation 34, due to the flexible nature of the inner portion 28). The force resulting from this displacement is capable of being detected by the load cell or strain gauge 56, or by another type of suitable force detection device.
    Alternative methods and mechanisms to detect the actuation or triggering of MDI 8 by patient 4 can also be used. For example, an acoustic microphone can be provided in package 34 to hear and detect sounds indicative of the actuation or triggering of MDI 8. As another alternative, a temperature sensor can be provided in package 34 to monitor the temperature inside main package 14 and detect a change in temperature (reduction) resulting from the introduction of aerosol mist by the actuation of MDI 8. As another alternative, the accelerometer 52 can be used to detect the movement of MDI 8 and, thus, of the respiratory medication delivery device 2 , resulting from the downward force applied to the container 10 to act the MDI 8. As yet another alternative, an IR emitter and detector can be used to detect the presence of aerosol being ejected
    16/23 by MDI 8 (the aerosol would interrupt the light beam). In particular, the emitter / detector pair would be positioned inside or outside the main chamber 14, with an orientation that is perpendicular to the aerosol mist, and, in an exemplary embodiment in which the feedback and compliance device 32 is combined with the adapter of MDI 24 as a one-piece set (described above), they would be part of the feedback and compliance device 32.
    In addition, alternative methods and mechanisms for detecting the insertion of MDI 8 into a feedback and compliance device 32 can also be employed. For example, as described in US provisional patent application US 61 / 091,546, owned by the holder, a resilient and flexible flap actuating member can be provided, which extends from the outer encapsulation 34 and is structured to extend partially over the central recess 36. When the MDI 8 is inserted into the feedback and compliance device 32, the tip of the flap actuating member is pushed down and against a key that is coupled to the processing unit 42. The actuation of the key in this realization indicates the insertion of MDI 8.
    The breath held by patient 4 can, in a particular embodiment, be detected and verified using flow sensor 54 and IR sensors 46, and / or the accelerometer 52. In one embodiment, processing unit 42 can detect and verify (and time) that patient 4 is holding his breath when detecting the end of an inhalation action using flow sensor 54, and determining that each of the following is true:
    (i) patient 4 did not exhale through the exhalation valve element 22, as determined by one of the IR sensors 46 (described elsewhere in this document), (ii) patient 4 did not move the delivery device
    17/23 breathing medication 2 and is holding the breathing medication delivery device 2 in place, as shown in Figure 5, as determined by the accelerometer 52, and (iii) the patient did not initiate another inhalation action, as determined by the flow 54. In another embodiment, processing unit 42 can detect and verify (and time) that patient 4 is holding his breath when detecting the end of an inhalation action using flow sensor 54, and determining that each of the following is true: (i) patient 4 did not exhale through the exhalation valve element 22, as determined by one of the IR sensors 46 (described elsewhere in this document), (ii) patient 4 is holding the device administration of respiratory medication 2 in place, as shown in Figure 5, as determined by another of the IR 46 sensors (described elsewhere in this document), and ( iii) the patient did not initiate another inhalation action, as determined by the flow sensor 54. The purpose of determining apnea is described elsewhere in this document, in connection with Figures 8A and 8B.
    In addition, in the exemplary embodiment, the feedback and compliance device 32 includes input device 60, such as a button or buttons, or a touch screen, to allow a patient 4 to send information to processing unit 42. The device feedback and compliance 32 also includes a loudspeaker 62 operatively coupled to processing unit 42 to provide audible outputs, such as instructions or other feedback, as described elsewhere in this document, to patient 4.
    Figures 8A and 8B are a flow chart illustrating the operation of the respiratory drug delivery apparatus 2, according to a particularly non-limiting embodiment of the invention. The method illustrated in Figures 8A
    18/23 and 8B is, in the exemplary embodiment, implemented in one or more programs / routines that are stored and executed by the processing unit 42 of the feedback and compliance device 32. The method starts at step 100, in which it is determined whether the MDI 8 was inserted in the feedback and compliance device 32. As described in other parts of this document, the determination can be made based on the detection of a force associated with such insertion by the load cell or extensometer 56, or by another detection mechanism automatic, such as a flap actuating member and associated key, provided as part of the feedback and compliance device 32. Alternatively, the determination can be made in response to patient 4 by acting on part of the input device 60 (for example, by pressing a button that is part of the input device 60) to indicate that MDI 8 has been inserted and that treatment can begin. If the answer to step 100 is yes, then, in step 102, processing unit 42 causes a first LED to turn green (for example, from a red initial state) and causes an audio instruction instructing patient 4 shaking the respiratory medication delivery device 2 is provided through loudspeaker 62. Then, in step 104, processing unit 42 determines whether the stirring of the respiratory medication delivery device 2 has been detected. As described elsewhere in this document, shaking can be detected using an accelerometer 52. If the answer to step 104 is no, then in step 106, the instructions for shaking are repeated and the method returns to step 102. If , however, the answer to step 104 is yes, so in step 108, processing unit 42 causes a second LED 48 to turn green (for example, from a red initial state), and causes audible instructions
    19/23 instructing patient 4 to act on MDI 8 within a predetermined time, such as 5 seconds, to be provided through speaker 62. In step 110, processing unit 42 determines whether MDI 8 was actually acted within the predetermined time 5 (for example, within 5 seconds after shaking). As described elsewhere in this document, this can be done by detecting the forces caused by such action using the load cell or extensometer 56.
    If the answer to step 110 is no, then in step 112, the second LED 48 is changed to red by the processing unit 42, and the processing unit 42 causes audible instructions to shake the respiratory medication delivery apparatus. 2 are again provided via speaker 62. The method then returns to step 104. If, however, the answer to step 110 is yes, then, in step 114, processing unit 42 causes a third LED 48 turns green (for example, from an initial red state), and causes audible instructions instructing patient 4 to inhale slowly and count to a predetermined number, such as five, through the loudspeaker 62. The method then proceeds to step 116 in Figure 8B. In step 116, processing unit 42 determines whether inhalation by patient 4 has been detected for at least a predetermined period of time, such as five seconds. As described elsewhere in this document, inhalation can be detected using flow sensor 54. If the answer in step 116 is no, then in step 118, processing unit 42 makes instructions, instructing a patient 4 to continue with inhalation, be provided through loudspeaker 62. The method then returns to step 116.
    If the answer in step 116 is yes, meaning
    20/23 that inhalation, for at least the predetermined period (for example, five seconds) has been detected, then, in step 12 0, the processing unit 4 2 causes a fourth LED 48 to turn green (for example , starting from a red initial state), and causes audible instructions, instructing patient 4 to hold their breath and count to a predetermined number, such as three, to be provided through speaker 62. Then, in step 140, processing unit 42 determines whether an apnea of at least a predetermined period of time, such as three seconds, has been detected. In the exemplary embodiment, apnea is detected as described elsewhere in this document, using IR sensors 46 and flow sensor 54 and / or the accelerometer 52 (Figure 5). If the answer in step 14 0 is 15, then in step 145, processing unit 42 causes an audible reminder to be provided via speaker 62, which indicates that patient 4 must hold his breath for at least a predetermined period of time, such as three seconds, when using the respiratory drug delivery device 2. If the answer to step 140 is yes, then, in step 150, processing unit 42 causes a fifth LED 48 turns green (for example, from an initial red state), and causes audible instructions, 25 indicating that the treatment has been completed, to be provided through speaker 62.
    Optionally, the processing unit 42 can be programmed to store information related to the use of the respiratory drug delivery apparatus 230 during one or more treatment sessions. Such stored information may include, for one or more treatment sessions, information related to determining whether each stage of operation of the drug delivery device
    21/23 respiratory 2 was properly performed (for example, if the LEDs turned green), and the timing and duration of such steps (for example, how long MDI 8 was shaken, how long it took, after MDI 8 was shaken , for MDI 8 to be activated, the duration of the detected inhalation, and the duration of the apnea detected). This information can then be downloaded and reviewed and / or analyzed by patient 4 and / or a patient's caregiver 4.
    Figures 10 and 11 are isometric front and rear views, respectively, of the respiratory drug delivery apparatus 70, according to an alternative exemplary embodiment of the invention. Figure 12 is a side cross-sectional view of the respiratory drug delivery device 70. In carrying out Figures 10 to 12, the respiratory drug delivery device 70 includes only MDI 8, which is coupled to the feedback and compliance device 72. In other words, carrying out Figures 10 to 12 does not require a spacer or valve support chamber to be used with the MDI 8. The feedback and compliance device 72 of the respiratory medication delivery device 70 is similar in functionality to the feedback and compliance device 32, and, in the exemplary embodiment, includes within the package 74 of it all components of the feedback and compliance device 32 shown in Figure 4 and described elsewhere in this document (similar components are labeled with similar reference). Referring to Figure 12, the feedback and compliance device 72 includes the flexible inner portion 28 mounted and supported within the rigid package 74. The flexible inner portion 28 includes walls that define a structured opening for receiving the boot 30 output from the MDI 8, as described elsewhere in this document, when boot 12 is received via
    22/23 of the central recess 78 of the package 74. The feedback and compliance device 72 also includes a nozzle 76 on a front end of the package 74, so that a central channel for drug flow exists through the package 74. As noted above , the feedback and compliance device 72 is structured to provide all the feedback and compliance features of the feedback and compliance device 32 described elsewhere in this document. The feedback and compliance device 72 thus provides a device to provide functionality that can be directly attached to the MDI 8 and used without a valve support chamber or spacer, since a patient can receive the medication directly through the mouthpiece 76.
    Although each of the exemplary embodiments of the present invention, described elsewhere in this document, employs a drug storage and delivery device in the form of a metered-dose inhaler (MDI), it should be understood that this is intended to be exemplary only, and not it is meant to be limiting. Other types of medication administration and storage devices known or subsequently developed can also be employed with the feedback and compliance device 32 or with the feedback and compliance device 72. For example, and without limitation, the feedback and compliance device 32 , or the feedback and compliance device 72, can be coupled and used with a dry powder inhaler (DPI) or with an aqueous liquid dispensing system.
    Although the invention has been described in detail, for the purpose of illustration, based on what is currently considered to be the most practical and preferred achievements, it should be understood that such details are only
    23/23 for this purpose, and that the invention is not limited to the revealed achievements, but, on the contrary, is intended to cover modifications and equivalent provisions that are within the spirit and scope of the attached claims. For example, it should be understood that the present invention contemplates that, as far as possible, one or more characteristics of any embodiment can be combined with one or more characteristics of any other embodiment.
    权利要求:
    Claims (15)
    [1]
    1. RESPIRATORY MEDICINE ADMINISTRATION APPLIANCE (2), characterized by comprising:
    a medication storage and delivery device (8) having an outlet (30); and a feedback and compliance device (32) coupled to the medicine storage and delivery device, the feedback and compliance device having an opening, the outlet of the medicine storage and delivery device being received through the opening, the feedback device and compliance including:
    (i) a plurality of sensors (46, 52, 54, 56), individual sensors of the sensors being configured to detect a parameter related to the use of the respiratory medication administration device without modifying or interfering with the flow of medication introduced by the action of the medication storage and delivery device, wherein the sensors include: (A) a motion sensor device (52) configured to detect agitation of the medication storage and delivery device, (B) a proximity sensor (46) configured for detecting a position of the respiratory drug delivery apparatus relative to a patient's face, (C) a flow sensor (54) configured to detect inhalation by the patient, in (ii) one or more feedback devices (48, 50,
    62), and (iii) a processing unit (42) programmed to cause one or more feedback devices to provide feedback information to a patient (4) related to the use of the respiratory medication delivery device based on the output at least one
    Petition 870190105704, of 10/18/2019, p. 6/16
    [2]
    2/8 or more sensors;
    wherein a position information is emitted from the proximity sensor (46), being used in connection with a fluid flow information emitted from the flow sensor (54), to determine whether the patient (4) is holding breathing as instructed.
    2. RESPIRATORY MEDICINE ADMINISTRATION APPARATUS, according to claim 1, characterized by the plurality of sensors additionally include:
    a force sensing device (56) configured to detect the performance of the medication storage and delivery device.
    [3]
    3. RESPIRATORY MEDICINE ADMINISTRATION APPLIANCE, according to claim 2, characterized in that the motion sensor device is an accelerometer (52), in which the flow sensor is a MEMS flow sensor (54), and in which the force sensing device is a load cell or an extensometer (56).
    [4]
    4. RESPIRATORY MEDICINE ADMINISTRATION APPARATUS, according to claim 2, characterized by the processing unit being programmed to cause one or more feedback devices to provide feedback information in the form of:
    (i) an instruction for shake The device in storage and administration in medicine, in response The determination that the device storage and administration of medicine was inserted at the device in feedback and compliance, (ii) an instruction to act The device in storage and administration in medicine, in response The
    determining that the medication storage and delivery device has been shaken, (iii) an instruction to inhale on a first
    Petition 870190105704, of 10/18/2019, p. 7/16
    3/8 in particular, in response to the determination that the drug storage and delivery device has been actuated, and (iv) an instruction instructing the patient to hold his breath in a particular second way, in response to the determination that inhalation in the first particular way has ended.
    [5]
    5. RESPIRATORY MEDICINE ADMINISTRATION APPARATUS, according to claim 2, characterized by the processing unit being programmed to cause one or more feedback devices to provide feedback information in the form of:
    (i) a first indication, indicating that the medication storage and delivery device has been properly inserted into the feedback and compliance device, in response to the determination that the medication storage and delivery device has been inserted into the feedback and compliance device, (ii) a second indication, indicating that the drug storage and delivery device has been properly agitated, in response to the determination that the drug storage and delivery device has been shaken, (iii) a third indication, indicating that the medication storage and administration was properly acted upon, in response to the determination that the medication storage and administration device was actuated, iv) a fourth indication, indicating that inhalation
    was properly fulfilled, in answer The determination in what inhalation in a first way in private was finalized, and (v) a fifth recommendation, indicating that The
    Petition 870190105704, of 10/18/2019, p. 8/16
    4/8 breathing was properly performed in response to the determination that the patient held his breath in a second particular way.
    [6]
    6. MEDICINE ADMINISTRATION APPLIANCE
    RESPIRATORY, according to claim 2, characterized in that the feedback and compliance device includes an encapsulation (34) defining the opening, the encapsulation including an upper portion located above the opening, a lower portion located below the opening, a front side and a rear side, the outlet extending outwards from the front side, in which the force sensing device is provided in the encapsulation in the lower portion.
    [7]
    7. RESPIRATORY MEDICINE ADMINISTRATION APPLIANCE, according to claim 6, characterized in that the lower portion includes a channel (38) extending completely through it, from the rear side to the front side, the channel being structured to allow fluid flow through the encapsulation, and where the flow sensor is positioned in the lower portion adjacent to the channel.
    [8]
    8. MEDICINE ADMINISTRATION APPLIANCE
    RESPIRATORY, according to claim 1, characterized in that the feedback and compliance device includes an encapsulation (34) defining the opening, the encapsulation including an upper portion located above the opening, a lower portion located below the opening, a front side and a rear side, the outlet extending outwards from the front side, where the proximity sensor (46) is provided in the upper portion of the front side.
    [9]
    9. FEEDBACK AND COMPLIANCE DEVICE (32) FOR USE WITH A MEDICINE STORAGE AND ADMINISTRATION DEVICE (8), characterized by comprising:
    an encapsulation (34) having an opening, the opening being structured to receive an output (34) from the
    Petition 870190105704, of 10/18/2019, p. 9/16
    5/8 medication storage and administration device (8);
    a plurality of sensors (46, 52, 54, 56), individual sensors of one or more sensors being configured to detect a parameter related to the use of the medication storage and administration device without modifying or interfering with a medication flow introduced by the actuation of the medication storage and delivery device, where the sensors include (A) a motion sensor device (52) configured to detect agitation of the medication storage and delivery device, (B) a proximity sensor (46) configured for detecting a position of the respiratory drug delivery apparatus relative to a patient's face, and (C) a flow sensor (54) configured to sense the patient's inhalation;
    one or more feedback devices (48, 50, 62); and a processing unit (42) programmed to cause one or more feedback devices to provide feedback information to a patient (4) related to the use of the respiratory drug delivery device based on the output of at least one of the sensors ;
    wherein a position information is emitted from the proximity sensor (46), being used in connection with a fluid flow information emitted from the flow sensor (54), to determine whether the patient (4) is holding breathing as instructed.
    [10]
    10. FEEDBACK AND COMPLIANCE DEVICE, according to claim 9, characterized by the plurality of sensors additionally include:
    a force sensing device (56) for detecting the performance of the medication storage and delivery device.
    Petition 870190105704, of 10/18/2019, p. 10/16
    6/8
    [11]
    11. FEEDBACK AND COMPLIANCE DEVICE, according to claim 10, characterized by the processing unit being programmed to make the one or more feedback devices provide feedback information in the
    5 way of:
    (i) an instruction to shake the medication storage and delivery device in response to the determination that the medication storage and delivery device has been inserted into the medication device
    10 feedback and compliance, (ii) an instruction to act on the medication storage and delivery device in response to the determination that the medication storage and delivery device has been shaken,
    (Iii) an instruction to inhale in a particular first way, in response to the determination that the medication storage and delivery device has been actuated, and (iv) an instruction instructing the patient to arrest
    20 your breathing in a second way in particular, in response to the determination that inhalation in the first way in particular has ended.
    [12]
    12. FEEDBACK AND COMPLIANCE DEVICE, according to claim 10, characterized in that the processing unit is programmed to cause the one or more feedback devices to provide feedback information in the form of:
    (i) a first indication, indicating that the drug storage and delivery device 30 has been properly inserted into the feedback and compliance device, in response to determining which drug storage and delivery device has been inserted into the feedback and compliance device,
    Petition 870190105704, of 10/18/2019, p. 11/16
    7/8 (ii) a second indication, indicating that the medicine storage and delivery device has been properly agitated, in response to the determination that the medicine storage and delivery device has been shaken, (iii) a third indication, indicating that the medication storage and administration device was properly acted upon, in response to the determination that the medication storage and administration device was actuated, (iv) a fourth indication, indicating that the inhalation was properly performed, in response to the determination that inhalation in a particular first manner was terminated, and (v) a fifth indication, indicating that the breath was properly performed, in response to the determination that the patient held his breath in a particular second way.
    [13]
    13. FEEDBACK AND COMPLIANCE DEVICE, according to claim 9, characterized in that it additionally comprises an adapter (24) structured to be coupled to a main chamber (14) of a valve support chamber (6), the adapter being structured to receive and hold the exit.
    [14]
    14. FEEDBACK AND COMPLIANCE DEVICE, according to claim 9, characterized in that the encapsulation is structured to be removably attached to an adapter (24) structured to be coupled to a main chamber (14) of a valve support chamber (6) , the adapter being structured to receive and hold the output.
    [15]
    15. FEEDBACK AND COMPLIANCE DEVICE, according to claim 9, characterized in that one or more sensors include a sensor to detect the opening of a
    Petition 870190105704, of 10/18/2019, p. 12/16
    8/8 exhalation valve (46) of a valve support chamber.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012016540B1|2020-03-24|RESPIRATORY MEDICINE ADMINISTRATION AND FEEDBACK DEVICE AND COMPLIANCE FOR USE WITH A MEDICINE STORAGE AND ADMINISTRATION DEVICE
    JP5746625B2|2015-07-08|Respiratory drug delivery device providing voice instructions
    US6039042A|2000-03-21|Portable chamber for metered dose inhaler dispensers
    JP5919277B2|2016-05-18|Holding chamber with valve including valve holding system
    US6718969B1|2004-04-13|Medication dosage inhaler system
    US6578571B1|2003-06-17|Drug delivery device and methods therefor
    US9956359B2|2018-05-01|Method and apparatus comprising stepped mouthpiece for aerosol drug delivery
    JP3213587U|2017-11-16|Nebulizer for infants and patients with respiratory failure
    US8141551B2|2012-03-27|Mouthpiece and flow rate controller for intrapulmonary delivery devices
    US20020104531A1|2002-08-08|Pediatric inhalation device
    EP3117858A1|2017-01-18|Nebulizer for infants and respiratory compromised patients
    EP1407794B1|2009-09-23|Asthma drug inhaler with whistle
    US20150059739A1|2015-03-05|Inhaler spacer
    ES2886974T3|2021-12-21|Inhaler
    US20200197654A1|2020-06-25|Nasal mask with aromatic dispenser
    Smith2012|Inhalation devices for asthma and chronic obstructive pulmonary disease
    JP3197551U|2015-05-21|Aspirator
    AU2013209385B2|2014-10-23|Nebulizer for infants and respiratory compromised patients
    Aylott2009|Non-invasive respiratory therapy
    TWM331377U|2008-05-01|Medication feeding device and connection tube used for medication feeding device
    同族专利:
    公开号 | 公开日
    JP5873805B2|2016-03-01|
    EP2521583B1|2020-10-28|
    CN102695535A|2012-09-26|
    US9352107B2|2016-05-31|
    BR112012016540A2|2018-10-16|
    WO2011083377A1|2011-07-14|
    JP2013516265A|2013-05-13|
    EP2521583A1|2012-11-14|
    US20130008436A1|2013-01-10|
    CN102695535B|2016-03-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4470412A|1982-03-19|1984-09-11|Trutek Research, Inc.|Inhalation valve|
    US4809692A|1986-01-31|1989-03-07|Trudell Medical|Pediatric asthmatic medication inhaler|
    US4832015A|1988-05-19|1989-05-23|Trudell Medical|Pediatric asthmatic inhaler|
    US4984158A|1988-10-14|1991-01-08|Hillsman Dean|Metered dose inhaler biofeedback training and evaluation system|
    US5012803A|1989-03-06|1991-05-07|Trudell Medical|Modular medication inhaler|
    SE466684B|1989-03-07|1992-03-23|Draco Ab|DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION|
    US5201753A|1989-03-17|1993-04-13|Merit Medical Systems, Inc.|Totally self-contained, digitally controlled, disposable syringe inflation system, and method for monitoring, displaying and recording balloon catheter inflation data|
    US5042467A|1990-03-28|1991-08-27|Trudell Medical|Medication inhaler with fitting having a sonic signalling device|
    US5469750A|1991-03-05|1995-11-28|Aradigm Corporation|Method and apparatus for sensing flow in two directions and automatic calibration thereof|
    AU651882B2|1991-05-14|1994-08-04|Visiomed Group Limited|Aerosol inhalation device|
    US5167506A|1991-10-24|1992-12-01|Minnesota Mining And Manufacturing Company|Inhalation device training system|
    AU3152993A|1991-12-16|1993-07-19|University Of Melbourne, The|Improvements in the administration of aerosol compounds|
    US5363842A|1991-12-20|1994-11-15|Circadian, Inc.|Intelligent inhaler providing feedback to both patient and medical professional|
    US5284133A|1992-07-23|1994-02-08|Armstrong Pharmaceuticals, Inc.|Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means|
    US5333106A|1992-10-09|1994-07-26|Circadian, Inc.|Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers|
    SE9401020D0|1994-03-25|1994-03-25|Astra Ab|Method and apparatus in connection with an inhaler|
    GB9421687D0|1994-10-27|1994-12-14|Aid Medic Ltd|Dosimetric spacer|
    US5809997A|1995-05-18|1998-09-22|Medtrac Technologies, Inc.|Electronic medication chronolog device|
    US5758638A|1995-07-24|1998-06-02|Kreamer; Jeffry W.|Indicator for a medicament inhaler|
    AU738905B2|1996-06-14|2001-09-27|Aktiebolaget Electrolux|A gas hob|
    US5794612A|1997-04-02|1998-08-18|Aeromax Technologies, Inc.|MDI device with ultrasound sensor to detect aerosol dispensing|
    US5848599A|1997-07-28|1998-12-15|Todd; Mark D.|Apparatus for crimping and tattooing hair|
    US6358058B1|1998-01-30|2002-03-19|1263152 Ontario Inc.|Aerosol dispensing inhaler training device|
    US6039042A|1998-02-23|2000-03-21|Thayer Medical Corporation|Portable chamber for metered dose inhaler dispensers|
    US6578571B1|1998-04-20|2003-06-17|Infamed Ltd.|Drug delivery device and methods therefor|
    WO1999064095A2|1998-06-12|1999-12-16|Microdose Technologies, Inc.|Metering, packaging and delivery of pharmaceuticals and drugs|
    US6240917B1|1999-12-20|2001-06-05|Joseph R. Andrade|Aerosol holding chamber for a metered-dose inhaler|
    US8820316B2|2000-02-11|2014-09-02|Respironics Respiratory Drug Delivery Ltd|Drug delivery apparatus|
    EP1944036A3|2000-02-11|2009-01-14|Profile Drug Delivery Ltd|Improvements in and relating to drug delivery|
    DE60114393T2|2000-04-11|2006-04-27|Trudell Medical International, London|AEROSOL DISPENSER WITH A POSSIBILITY FOR POSITIVE EXHAUST PRINTING|
    WO2002005879A1|2000-07-15|2002-01-24|Glaxo Group Limited|Medicament dispenser|
    JP2004522514A|2001-01-25|2004-07-29|クリニカル・デザインズ・リミテッド|Drug dosing device|
    US6571971B1|2001-02-08|2003-06-03|Weller Engineering, Inc.|Hermetically sealed container with pierceable entry port|
    GB0108228D0|2001-04-02|2001-05-23|Glaxo Group Ltd|Medicament dispenser|
    CA2459867C|2001-09-06|2012-03-13|Microdose Technologies, Inc.|Adaptors for inhalers to improve performance|
    US6684880B2|2001-12-04|2004-02-03|Hewlett-Packard Development Company, L.P.|Applicator for dispensing bioactive compositions and methods for using the same|
    US6830046B2|2002-04-29|2004-12-14|Hewlett-Packard Development Company, L.P.|Metered dose inhaler|
    AU2003225071A1|2002-05-03|2003-11-17|Trudell Medical International|Aerosol medication delivery apparatus with narrow orifice|
    US6904908B2|2002-05-21|2005-06-14|Trudell Medical International|Visual indicator for an aerosol medication delivery apparatus and system|
    US6904907B2|2002-11-19|2005-06-14|Honeywell International Inc.|Indirect flow measurement through a breath-operated inhaler|
    GB2406283B|2003-09-24|2006-04-05|Altana Pharma Ag|Compliance monitor and method|
    JP2007522902A|2004-02-24|2007-08-16|ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング|Nebulizer|
    WO2005123165A1|2004-06-15|2005-12-29|Novo Nordisk A/S|Inhalation breath assistant apparatus and method for assisting in inhalation therapies|
    US20060130838A1|2004-12-20|2006-06-22|Lee Yong Y|Data logger for monitoring asthmatic conditions|
    EP2125075A2|2007-01-22|2009-12-02|Intelliject, Inc.|Medical injector with compliance tracking and monitoring|
    WO2010023591A2|2008-08-25|2010-03-04|Koninklijke Philips Electronics N.V.|Respiratory drug delivery apparatus which provides audio instructions|
    US9154608B2|2012-05-09|2015-10-06|Facebook, Inc.|Data exchange between antenna and modem of mobile device|WO2011073806A1|2009-12-16|2011-06-23|Koninklijke Philips Electronics N.V.|Color identification for drug delivery system|
    US10857311B2|2010-01-12|2020-12-08|Omega Life Science Ltd.|Method and apparatus for producing fine concentrated aerosol|
    US9883786B2|2010-05-06|2018-02-06|Aic Innovations Group, Inc.|Method and apparatus for recognition of inhaler actuation|
    JP5919277B2|2010-09-21|2016-05-18|コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ．|Holding chamber with valve including valve holding system|
    NZ595367A|2011-09-23|2012-02-24|Nexus6 Ltd|A dose counting mechanism adapted to enclose a medicament delivery device|
    WO2013061240A1|2011-10-27|2013-05-02|Koninklijke Philips Electronics N.V.|Systems and methods for combined respiratory therapy and respiratory monitoring|
    GB2496684A|2011-11-21|2013-05-22|Adi Wallach|Breathing biofeedback device optionally comprising inhalable substance dispenser and breathing feedback methods|
    WO2013098334A1|2011-12-27|2013-07-04|Activaero Gmbh|Inhalation device with feedback system|
    KR101792905B1|2011-12-30|2017-11-02|필립모리스 프로덕츠 에스.에이.|Aerosol generating device with air flow detection|
    GB201202926D0|2012-02-21|2012-04-04|Central Manchester University Hospitals Nhs Foundation Trust|Inhaler spacer|
    GB2502055A|2012-05-14|2013-11-20|Nicoventures Holdings Ltd|Modular electronic smoking device|
    ES2821811T3|2012-06-25|2021-04-27|Gecko Health Innovations Inc|Devices, systems and methods for monitoring compliance and patient interaction|
    FR2993783B1|2012-07-26|2015-06-05|Protecsom|INHALATION DEVICE FOR ADMINISTERING DRUG SUBSTANCE DURING INHALATION TREATMENT|
    EP2890301B1|2012-08-29|2019-10-09|The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin|System for monitoring use of a device|
    EP2903672B1|2012-10-04|2018-01-10|Boehringer Ingelheim International GmbH|System, method and use for training an inhalation process|
    GB2507103A|2012-10-19|2014-04-23|Nicoventures Holdings Ltd|Electronic inhalation device|
    EP2724741B1|2012-10-26|2017-06-14|Vectura GmbH|Inhalation device for use in aerosol therapy|
    US9700688B2|2013-03-15|2017-07-11|Trudell Medical International|Delivery device and kit, and method of use|
    WO2014140774A1|2013-03-15|2014-09-18|Trudell Medical International|Delivery device and kit, and method of use|
    JP6620085B2|2013-03-21|2019-12-11|コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ．|System and method for monitoring use of a respiratory drug delivery device|
    GB201306709D0|2013-04-12|2013-05-29|Clement Clarke Int Ltd|Training device|
    US8807131B1|2013-06-18|2014-08-19|Isonea Limited|Compliance monitoring for asthma inhalers|
    GB201310824D0|2013-06-18|2013-07-31|Smiths Medical Int Ltd|Respiratory therapy apparatus and methods|
    EP3019226B1|2013-07-09|2021-10-13|Koninklijke Philips N.V.|Ultrasonic energy measurements in respiratory drug delivery devices|
    EP3019227B1|2013-07-09|2019-06-19|Koninklijke Philips N.V.|Ultrasonic measurements for monitoring patients using respiratory therapy delivery devices|
    JP6475710B2|2013-07-09|2019-02-27|コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ．|System and method for delivering a drug to a subject|
    WO2015024650A1|2013-08-20|2015-02-26|Boehringer Ingelheim Vetmedica Gmbh|Inhaler|
    PL3035886T3|2013-08-20|2021-05-31|Boehringer Ingelheim Vetmedica Gmbh|Inhaler|
    DK3035887T3|2013-08-20|2020-03-16|Boehringer Ingelheim Vetmedica Gmbh|INHALER|
    DK3038687T3|2013-08-28|2019-04-15|Gecko Health Innovations Inc|DEVICE MONITORING DEVICES AND CONSUMER SUPPLY MONITORING DEVICES|
    TWI572377B|2013-10-04|2017-03-01|財團法人國家實驗研究院|Medication recording apparatus and method|
    GB2519101A|2013-10-09|2015-04-15|Nicoventures Holdings Ltd|Electronic vapour provision system|
    US10019555B2|2013-10-19|2018-07-10|Cohero Health, Inc.|Interactive respiratory device usage tracking system|
    US10304314B2|2013-10-31|2019-05-28|Kali Care, Inc.|Method of and apparatus for targeted interactive health status notification and confirmation|
    WO2015109259A1|2014-01-16|2015-07-23|Focusstart Respiratory Llc|Systems and methods for managing pulmonary medication delivery|
    CN106163595B|2014-03-03|2020-07-24|安瑞智能有限公司|Compliance monitor for dry powder drug delivery device|
    EP3116394A4|2014-03-10|2017-12-06|respEQ Inc.|Systems and methods for delivering an agent to a user's lungs and for simultaneously monitoring lung health|
    WO2015144442A1|2014-03-25|2015-10-01|Koninklijke Philips N.V.|Inhaler with two microphones for detection of inhalation flow|
    KR20160142291A|2014-04-07|2016-12-12|베링거 인겔하임 인터내셔날 게엠베하|Inhalation training device and system for practicing of an inhalation process of a patient|
    HUE049888T2|2014-04-07|2020-11-30|Boehringer Ingelheim Int|Method, electronic device, inhalation training system for practicing and/or controlling an inhalation process of a patient|
    US10173025B2|2014-04-21|2019-01-08|Idtx Systems, Inc.|Automated drug delivery systems|
    EP3142735A4|2014-05-16|2018-01-24|AdheriumLimited|Devices and methods for identification of medicament delivery devices|
    FR3021544B1|2014-05-30|2017-06-23|Assist Publique - Hopitaux De Paris|INHALATION DEVICE OPTIMIZED FOR USE ON A CHILD|
    CA2950982A1|2014-06-13|2015-12-17|Microdose Therapeutx, Inc.|Medical device communication|
    FR3024655A1|2014-08-06|2016-02-12|Nemera La Verpilliere|PHARMACEUTICAL PREPARATION DELIVERY DEVICE|
    CN106999681B|2014-08-28|2021-02-02|诺顿（沃特福特）有限公司|Compliance aid module for an inhaler|
    MX2017002550A|2014-08-28|2017-05-25|Microdose Therapeutx Inc|Compliance monitoring module for an inhaler.|
    US11033694B2|2014-09-22|2021-06-15|Koninklijke Philips N.V.|Inhaler with orientation sensor|
    WO2016055655A1|2014-10-10|2016-04-14|Ablynx N.V.|Inhalation device for use in aerosol therapy of respiratory diseases|
    CA2962906A1|2014-10-13|2016-04-21|Omega Life Science Ltd.|Nebulizers and uses thereof|
    GB201420039D0|2014-11-11|2014-12-24|Teva Uk Ltd|System for training a user in administering a medicament|
    US10561814B2|2014-11-19|2020-02-18|Idtx Systems, Inc.|Automated drug dispensing systems with automated HME bypass for ventilator circuits|
    AU2015350319A1|2014-11-20|2017-06-15|Cognita Labs, LLC|Method and apparatus to measure, aid and correct the use of inhalers|
    US20160144142A1|2014-11-24|2016-05-26|Jeff Baker|Metered dose respiratory training device and system|
    ES2842173T3|2015-01-09|2021-07-13|Adherium Nz Ltd|Monitoring device for a drug inhaler|
    WO2016116591A1|2015-01-22|2016-07-28|Koninklijke Philips N.V.|Feature assigned inhalation aid|
    USD757926S1|2015-03-10|2016-05-31|Reciprocal Labs Corporation|Usage monitoring attachment for a soft mist inhaler|
    USD774178S1|2015-03-10|2016-12-13|Reciprocal Labs Corporation|Usage monitoring attachment for a dry powder inhaler|
    GB2537150A|2015-04-09|2016-10-12|Univ Manchester|Inhaler spacer|
    WO2016165029A1|2015-04-17|2016-10-20|Protecsom Amerique Du Nord Inc.|Optical flow measuring apparatus and inhalation apparatus comprising the same|
    GB2540135B|2015-07-01|2021-03-03|Nicoventures Holdings Ltd|Electronic aerosol provision system|
    US11040156B2|2015-07-20|2021-06-22|Pearl Therapeutics, Inc.|Aerosol delivery systems|
    GB201514372D0|2015-08-13|2015-09-30|Selex Es Ltd|Monitoring systems and methods|
    CN105056355B|2015-09-02|2018-01-02|广州医科大学附属第一医院|A kind of oral administration device with data statistics and upload function|
    WO2017071879A1|2015-10-30|2017-05-04|Koninklijke Philips N.V.|Breathing training, monitoring and/or assistance device|
    GB201600539D0|2016-01-12|2016-02-24|British American Tobacco Co|Visualisation system and method for electronic vapour provision systems|
    WO2017125853A1|2016-01-19|2017-07-27|Novartis Ag|Multidose inhaler|
    WO2017141194A1|2016-02-17|2017-08-24|AdheriumLimited|Adherence monitor for a medicament inhaler with tethered cap|
    MX2018011522A|2016-03-24|2019-07-04|Trudell Medical Int|Respiratory care system with electronic indicator.|
    JP2019510614A|2016-04-08|2019-04-18|オカラハン，クリス エルＯ‘Ｃａｌｌａｇｈａｎ，Ｃｈｒｉｓ Ｌ|Device and method for monitoring compliance with inhalation therapy|
    WO2017180107A1|2016-04-12|2017-10-19|Noble International, Inc.|Metered dose inhaler training device|
    BR112018070608A2|2016-04-12|2019-02-05|Biocorp Production SA|complementary device for metered dose inhalers, compliance enhancement system and method for improving compliance with use on metered dose inhalers|
    MX2018014121A|2016-05-19|2019-04-29|Trudell Medical Int|Smart valved holding chamber.|
    CN109496146A|2016-05-27|2019-03-19|优尼瓦健康公司|Device and method for using medicament device|
    US20170354793A1|2016-06-09|2017-12-14|Alaaeldin Soliman|Respiratory device to tracheostomy tube connector|
    GB2556016A|2016-06-20|2018-05-23|Smartair Medical Ltd|Device for monitoring medication intake|
    WO2018001840A1|2016-06-29|2018-01-04|Koninklijke Philips N.V.|Method and device for health devices and wearable/implantable devices|
    CA3028604A1|2016-07-08|2018-01-11|Trudell Medical International|Smart oscillating positive expiratory pressure device|
    US10189632B2|2016-09-12|2019-01-29|Altria Client Services Llc|Aerosol-generating system|
    ES2708855T3|2016-09-30|2019-04-11|Presspart Gmbh & Co Kg|Metering inhaler to administer aerosol doses|
    CN109890437B|2016-11-01|2021-11-19|赛诺菲-安万特德国有限公司|Auxiliary device for an injection device|
    WO2018083711A1|2016-11-03|2018-05-11|Saini Ajay Kumar|A respiratory monitoring system, a respiratory device and a method for intake of medicine from said respiratory device|
    US10368801B2|2016-11-17|2019-08-06|Shaviodla Shanta McGhee|Automatic medication dispenser with electronic thermometer|
    WO2018109224A1|2016-12-16|2018-06-21|Koninklijke Philips N.V.|Training device for an inhaler, and an inhaler|
    IT201700086905A1|2017-07-28|2019-01-28|Amiko S R L|Accessory for inhaler, inhaler and method for detecting a drug administration process|
    USD882754S1|2017-12-20|2020-04-28|Presspart Gmbh & Co. Kg|Inhaler|
    AU2019205865A1|2018-01-04|2020-07-16|Trudell Medical International|Smart oscillating positive expiratory pressure device|
    US11071836B2|2018-03-29|2021-07-27|Reciprocal Labs Corporation|Single dose inhaler monitoring attachment|
    CN208354595U|2018-04-11|2019-01-11|微邦科技股份有限公司|It is atomized liquid container and its intake and exhaust part|
    KR101907093B1|2018-05-18|2018-10-11|쓰리에스|Portable apparatus for discharging expectoration|
    KR101907099B1|2018-05-18|2018-10-11|쓰리에스|Portable apparatus for discharging expectoration with exhalation sensing function|
    EP3801714A4|2018-06-04|2022-03-09|Trudell Medical Int|Smart valved holding chamber|
    EP3741289A1|2019-05-20|2020-11-25|Flaem Nuova S.p.A.|Universal apparatus for checking and controlling breathing|
    法律状态:
    2018-11-13| B25D| Requested change of name of applicant approved|Owner name: KONINKLIJKE PHILIPS N.V. (NL) |
    2018-12-04| B25G| Requested change of headquarter approved|Owner name: KONINKLIJKE PHILIPS N.V. (NL) |
    2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-07-23| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-01-21| B09A| Decision: intention to grant|
    2020-03-24| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/12/2010, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US29302010P| true| 2010-01-07|2010-01-07|
    US61/293,020|2010-01-07|
    PCT/IB2010/055642|WO2011083377A1|2010-01-07|2010-12-07|Respiratory drug delivery apparatus including a feedback and compliance device|
    [返回顶部]